Castlemanâ??s disease (CD) is a rare non-clonal lymphadenopathy. Application of video-assisted\nthoracoscopic surgery (VATs) in intrathoracic unicentric Castlemanâ??s disease (UCD) is rarely reported. This study is\naimed to clarify the role of VATs for diagnosis and treatment in intrathoracic UCD.\nMethods: The authors reviewed and identified patients who had received a histologic diagnosis of CD through\nVATs at our hospital from January2010 to June 2018. Clinical and radiologic variables, histopathology, type of\napproach, complications, and long-term effect were analyzed to evaluate the safety and efficacy of VATs.\nResults: A total of 10 patients were included in this study, with 8 hyaline vascular type and 2 plasma cell type. The\nmean maximum diameter of the lesions was 4.66 cm. Nine cases underwent complete surgical excision by VATs,\nand 1 case was converted to thoracotomy. All patients had no postoperative complications. With a median followup\nof 5 years (range: 1-9 years), no tumor recurrence was found in 9 patients receiving complete tumor resection,\nand 1 patient with incomplete tumor resection remained symptom free without clinical or radiographic progression.\nConclusions: VATs is an alternative, minimally invasive technique for the diagnosis and treatment in patients with\nintrathoracic UCD.
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