Background: The clinical incidence of appendiceal mucinous adenocarcinoma is low. Moreover, the case reports of\npostoperative relapse after surgery are rarely based on literature search results. Here, we report such a case\nspanning nearly 7 years and and review the relevant literature.\nCase presentation: A 50-year-old female underwent additional surgery after appendectomy, and pathological\nexamination confirmed mucinous adenocarcinoma. The patients underwent HIPEC (hyperthermic intraoperative\nchemotherapy) and adjuvant chemotherapy. Twenty-six months after the previous surgeries, another surgery, HIPE\nC, and adjuvant chemotherapy were performed again due to tumour recurrence. To date, the follow-up time is 43\nmonths, and no recurrence or metastasis has been found.\nConclusions: Appendix mucinous adenocarcinoma has a poor prognosis and the diagnosis depends on\npathological and immunohistochemical examinations. Its clinical manifestations are non-specific, and CRS + HIPEC\nshould be used for treatment, which is safe and effective.
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