Wound healing is a complex pathway of regulated reactions and cellular infiltrates. The mechanisms at play have been thoroughly\nstudied but there is much still to learn. The health care system in the USA alone spends on average 9 billion dollars annually on\ntreating of wounds. To help reduce patient morbidity and mortality related to abnormal or prolonged skin healing, an updated\nreview and understanding of wound healing is essential. Recent works have helped shape the multistep process in wound healing\nand introduced various growth factors that can augment this process. The complement cascade has been shown to have a role in\ninflammation and has only recently been shown to augment wound healing. In this review, we have outlined the biology of wound\nhealing and discussed the use of growth factors and the role of complements in this intricate pathway.
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