Objective.Thestudy was to investigate the impact of orthotropic material on the biomechanics of dental implant, based on a detailed\nmandible with high geometric and mechanical similarity. Materials and Methods. Multiple data sources were used to elaborate\ndetailed biological structures and implant CAD models. In addition, an extended orthotropic material assignment methodology\nbased on harmonic fields was used to handle the alveolar ridge region to generate compatible orthotropic fields. The influence\nof orthotropic material was compared with the commonly used isotropic model and simplified orthotropic model. Results. The\nsimulation results showed that the values of stress and strain on the implant-bone interface almost increased in the orthotropic\nmodel compared to the isotropic case, especially for the cancellous bone. However, the local stress concentration was more obvious\nin the isotropic case compared to that in orthotropic case. The simple orthotropic model revealed irregular stress and strain\ndistribution, compared to the isotropicmodel and the real orthotropicmodel.The influence of orthotropy was little on the implant,\nperiodontal ligament, tooth enamel, and dentin. Conclusion. The orthotropic material has significant effect on stress and strain\nof implant-bone interface in the mandible, compared with the isotropic simulation. Real orthotropic mechanical properties of\nmandible should be emphasized in biomechanical studies of dental implants
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