The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits.\nThe drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant\nis hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the\nefficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose\nwas delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the\ncurve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can\ndeliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis\nfor a novel approach to treating patients with chronic diseases.
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