Background. Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria\nis not uncommon and has detrimental consequences on renal allograft survival. A putative circulating permeability factor has been\nimplicated in the pathogenesis leading to widespread use of plasma exchange (PLEX).We reviewed published studies to assess the\nrole of PLEX on treatment of rFSGS in adults. Methods. Eligible manuscripts compared PLEX or variants with conventional care\nfor inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and reference lists. Data were abstracted\nin parallel by two reviewers. Results.We detected 6 nonrandomized studies with 117 cases enrolled. In a random effects model, the\npooled risk ratio for the composite endpoint of partial or complete PR was 0,38 in favour of PLEX (95% CI: 0,23ââ?¬â??0,61).No statistical\nheterogeneity was observed among included studies (
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