After undergoing liver transplantation, children are susceptible to oral lesions due to immunosuppressant drugs that\nare needed to maintain the transplant. In this context, it is important to understand how disease characteristics and\nage at transplantation influence the development of these lesions. Monitoring of lesions begins after transplantation\nand children are usually observed by a specialist in stomatology at periodic visits. Consequently, lesion development\nis estimated to occur between two observed times, and this is characterized as interval-censored data. However, in\nclinical practice, it is common to assume the moment of observation as the time of event occurrence, thereby\nexcluding interval-censored data. Here, we discuss the impact of excluding interval-censored mechanisms in\nstatistical analyses by using simulation studies to consider differences in sample sizes and amplitudes between\nobserved intervals. Then, application studies are presented which use a data set from a prospective study that was\nconducted to investigate oral lesions in patients after liver transplantation at the A.C.Camargo Cancer Center in Brazil\nbetween 2013 and 2016 and a data set involving recurrent ovarian cancer in patients diagnosed with high-grade\nserous carcinoma at the A.C.Camargo Cancer Center between 2003 and 2016.
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