Background. Individuals after solid organ transplant may develop secondary malignancies. In our clinical practice, we noted an\nincreasing number of individuals who developed colorectal cancers after solid organ transplantation.The primary aim of this study\nwas to describe the characteristics and outcomes of the patients who developed colorectal cancer after solid organ transplant.\nMaterials and Methods. Data was gathered andmerged fromseveral registries atMayo Clinic to identify all patients who received a\ndiagnosis of colon or rectal cancer and solid organ transplant. Continuous variables were summarized asmean (standard deviation)\nand median (range), while categorical variables were reported as frequency (percentage). Time to colorectal cancer after transplant\nand overall survival after cancer diagnosis were estimated using Kaplan-Meier method. Results. Initially, 115 colorectal cancer\npatients who also had a transplant were identified. The diagnosis of colorectal cancer was noted after solid organ transplant in\n63 patients.The mean age at transplant was 57 years. Majority had received a kidney transplant (44.4%) followed by liver (36.5%).\nThe median time to develop colorectal cancer was 59.3 months (range: 4.4-251.4 months). 15 (24.6%) were stage 4 at diagnosis\nand 13 (21.3%) had stage 3 colorectal cancer. Median overall survival was 30.8 months; 5-, 10- and 15-year survival were noted to\nbe 42.5%, 17.9%, and 7.5%, respectively. None of the stage 4 patients were alive at 5 years; 5-year survival rate for stage 1, 2, and 3\npatients was 77%, 50%, and 42%, respectively. Conclusions. Our study reports on one of the largest cohorts of patients of colorectal\ncancer that developed the cancer after solid organ transplant. Survival is extremely poor for advanced cases. However, long-term\nsurvivors are noted who developed the cancer at a relatively early stage. Colorectal screening recommendations may need to be\nrevised for patients after solid organ transplant.
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