Background and Objective. A common reconstruction procedure after a wide resection of bone tumors around the knee is\nendoprosthetic knee replacement. The aim of this study was to investigate the characteristics of bone injury of the patient after\nendoprosthetic knee replacement during walking. Methods. A subject-specific finite element model of the femur-prosthesis-tibia\ncomplex was established via CT scans. To obtain its physiologically realistic loading environments, the musculoskeletal inverse\ndynamic analysis was implemented. The extracted muscle forces and ground forces were then applied to the finite element\nmodel to investigate bone stress distribution at various stages of the gait cycle. Results. The maximum femur stress of each stage\nvaried from 33.14 MPa to 70.61 MPa in the gait cycle. The stress concentration position with a distance of 267.2mm to the tibial\nplateau showed a good agreement with the patient injury data. Conclusions. Overall results indicated the reasonability of the\nsimulation method to determine loading environments and injury characteristics which the patient experienced with knee\nendoprosthesis during walking.
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