A terbinafine impregnated subcutaneous implant was evaluated to determine if drug was released into isotonic saline over the\r\ncourse of 6 months at two different temperatures, 37?C and 4?C. These temperatures were chosen to simulate the nonhibernating\r\n(37?C) and hibernating body (4?C) temperatures of little brown bats (Myotis lucifugus). Insectivorous bats of North America,\r\nincluding little brown bats, have been devastated by white nose syndrome, a fungal infection caused by Geomyces destructans. No\r\ntreatments exist for bats infected with G. destructans. Implants were placed into isotonic saline; samples were collected once per\r\nweek and analyzed with HPLC to determine terbinafine concentrations. The mean amount of terbinafine released weekly across\r\nthe 28 weeks was approximately 1.7 �µg at 4?C and 4.3 �µg at 37?C. Although significant differences in the amount released did\r\noccur at some time points, these differences were not consistently greater or less at either of the temperatures. This study showed\r\nthat terbinafine was released from an impregnated implant over the course of 6 months at concentrations ranging from 0.02 to\r\n0.06 �µg/mL depending on temperature, which may be appropriate for little brown bats (Myotis lucifugus) infected with Geomyces\r\ndestructans, the etiologic agent of white nose syndrome.
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