consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant\nof papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better\nreflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including\npapillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. Fromamolecular standpoint, NIFTP\nis often characterized by RAS-type mutations, similar to other follicular-patterned lesions.While there has been prior evidence in\nthe literature for the low malignant potential of these tumors, projects moving forward will help to independently reinforce the\nreliability of these criteria and nomenclature.With planned inclusion of NIFTP into the latest World Health Organization endocrine\ntumor classification scheme, this nomenclature shift provides a model for pathology efforts to refine diagnostic classifications to\nbetter guide treatment. In this review we discuss this nomenclature change and review the current literature.
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