Background: The study aims to investigate the clinicopathological features and surgical outcomes of neuroendocrine\ntumors of ampulla of Vater (NETAoVs) patients who underwent pancreaticoduodenectomy.\nMethods: From January 2007 to December 2014, 45 patients underwent pancreaticoduodenectomy for malignant\ndisease of the ampulla of Vater in our institution. Of those, 5 patients were diagnosed as neuroendocrine tumors. The\ndata included age, sex, presenting symptoms, preoperative imaging, preoperative type of biopsy results, type of\noperation, pathologic findings and survival status.\nResults: The patientââ?¬â?¢s mean age was 55.2 Ã?± 9.7 years. Endoscopic ultrasound guided biopsy was performed in 4\npatients and gastroduodenoscopic biopsy was performed in one patient. All showed neuroendocrine tumor without\nmitosis. Mean tumor size was 1.9 Ã?± 0.56 cm (range, 1.2ââ?¬â??2.0 cm). Lymph node metastases were detected in two\npatients. All patients were synaptophysin-positive. Median periods of follow-up were 45 months (range, 43ââ?¬â??78 months).\nRecurrence after operation occurred in two patients. 4 patients were alive at the last follow-up.\nConclusions: Radical resection for NETAoVs can provide the information of status of lymph node metastasis after\nsurgery. However, correlation between lymph node metastasis and overall survival is uncertain to date.
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