Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several\ncommonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility\nof p53 expression in HCC has remained elusive. Aim. To evaluate the prognostic value of p53 and p53 phosphorylation at serine\n15 (p53 Ser15-P) in patients with HCC. Methods. Surgically resected tumors from 199 HCC patients were analyzed for p21, p53,\np53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry. Results. Stratifying by the\nexpression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients\nwithHCC.Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-Pâ??negative had significantly\nworse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-Pâ??positive. Conclusions. P53 Ser15-P is\nassociated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients\nwith PCNA-positive HCC.
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