Expression of forkhead box P3 (FOXP3), a key regulator of T-cell function, in the tumor immune\nmicroenvironment is related to survival in classic Hodgkin lymphoma (CHL). Vitamin D receptor (VDR), a\ntranscription factor agonists have been shown to induce FOXP3 expression in T-cells and enhance recruitment of\nthese cells to the inflammatory sites. VDR expression is CHL has been described. However, there is no data on\nexpression of VDR in context of quantity of FOXP3 positive cells in CHL.\nMethods: We examined and correlated immunohistochemical expression of VDR and FOXP3 along with clinical\nand pathology findings in 29 cases of CHL.\nResults: VDR was expressed in Hodgkin Reed-Sternberg (HRS) cells and background lymphocytes and FOXP3 was\nexpressed in background lymphocytes. 82% of CHL cases, regardless of the subtype, expressed VDR and in majority\nof the cases, VDR expression was directly proportional to the quantity of FOXP3 expressing lymphocytes in the\ntumor microenvironment. In cases with higher clinical stage......................
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