Glucose mobilization and utilization in the periphery and central nervous system are important during exercise and are\r\nresponsible for exercise efficacy. Magnesium (Mg) is involved in energy production and plays a role in exercise performance.\r\nThis study aimed to explore the effects of Mg on the dynamic changes in glucose and lactate levels in the muscle, blood and\r\nbrain of exercising rats using a combination of auto-blood sampling and microdialysis. Sprague-Dawley rats were pretreated\r\nwith saline or magnesium sulfate (MgSO4, 90 mg/kg, i.p.) 30 min before treadmill exercise (20 m/min for 60 min). Our\r\nresults indicated that the muscle, blood, and brain glucose levels immediately increased during exercise, and then gradually\r\ndecreased to near basal levels in the recovery periods of both groups. These glucose levels were significantly enhanced to\r\napproximately two-fold (P,0.05) in the Mg group. Lactate levels in the muscle, blood, and brain rapidly and significantly\r\nincreased in both groups during exercise, and brain lactate levels in the Mg group further elevated (P,0.05) than those in\r\nthe control group during exercise. Lactate levels significantly decreased after exercise in both groups. In conclusion, Mg\r\nenhanced glucose availability in the peripheral and central systems, and increased lactate clearance in the muscle during\r\nexercise.
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