Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow\ninfiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal\nheterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel\nstudies have also highlighted the importance of the functional cross-talk between the tumor clone\nand the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings\nhave certainly enhanced our understanding of the underlying mechanisms supporting MM\npathogenesis and disease progression. Within the specific field of small non-coding RNA-research,\nrecent studies have provided evidence for considering microRNAs as a crucial regulator of MM\nbiology and, in this context, circulating microRNAs have been shown to potentially contribute to\nprognostic stratification of MM patients. The present review will summarize the most recent studies\nwithin the specific topic of microRNAs and circulating microRNAs in MM.
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