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Inventi Impact: Genetics

Articles

  • Inventi:hgt/29824/19
    RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
    Research 2019 : October - December
    Maria Nowacka-Zawisza, Agata Raszkiewicz, Tomasz Kwasiborski, Ewa Forma, Magdalena Brys, Waldemar Rozanski, Wanda M Krajewska

    Genetic polymorphisms in DNA repair genesmay affect DNA repair efficiency andmay contribute to the risk of developing cancer.\nThe aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789)\nand XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer.The study group\nincluded 99men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP\nmethod. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism\nand an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate\ncancer.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Nowacka-Zawisza, Maria, et al. \"RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer.\" Journal of oncology 2019 (2019).\nhttps://doi.org/10.1155/2019/2976373\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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