Background: We have performed this study to evaluate the association between H19 rs217727 polymorphism and\nthe risk of cancer.\nMethods: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association.\nResults: A total of 17 caseâ??control publications were selected. This meta-analysis showed that H19 rs217727 has a\nsignificant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive\nmodels (T vs C: OR = 1.16, 95% CI = 1.06â??1.27, I2 = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06â??1.56, I2 = 71.6; CT vs CC:\nOR = 1.15, 95% CI = 1.01â??1.31, I2 = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05â??1.36, I2 = 76.5; TT vs CT + CC: OR =\n1.22, 95% CI = 1.02â??1.45, I2 = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers\nshowed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models.\nConclusion: This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.
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