Praderâ??Willi syndrome (PWS) is a rare disorder caused by the loss of expression of genes\non the paternal copy of chromosome 15q11-13. The main molecular subtypes of PWS are the deletion\nof 15q11-13 and non-deletion, and differences in neurobehavioral phenotype are recognized between\nthe subtypes. This study aimed to investigate growth trajectories in PWS and associations between\nPWS subtype (deletion vs. non-deletion) and height, weight and body mass index (BMI). Growth data\nwere available for 125 individuals with PWS (63 males, 62 females), of which 72 (57.6%) had the\ndeletion subtype. There was a median of 28 observations per individual (range 2-85), producing\n3565 data points distributed from birth to 18 years of age. Linear mixed models with cubic splines,\nsubject-specific random effects and an autoregressive correlation structure were used to model the\nlongitudinal growth data whilst accounting for the nature of repeated measures. Height was similar\nfor males in both PWS subtypes, with non-deletion females being shorter than deletion females\nfor older ages. Weight and BMI were estimated to be higher in the deletion subtype compared\nto the non-deletion subtype, with the size of difference increasing with advancing age for weight.\nThese results suggest that individuals with deletion PWS are more prone to obesity.
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