Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited\neffective treatments. Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been\nprescribed for nearly 400 years in China and shows good efficacy in promoting healing. In this study, we explored the effect\nof TLXDS on healing of diabetic wounds and investigated underlying mechanisms. Four weeks after intravenous injection of\nstreptozotocin, two full-thickness excisional wounds were created with a 10 mm diameter sterile biopsy punch on the back of rats.\nThe ethanol extract of TLXDS was given once daily by oral gavage. Wound area, histological change, inflammation, angiogenesis,\nand collagen synthesis were evaluated. TLXDS treatment significantly accelerated healing of diabetic rats and improved the healing\nquality. These effects were associated with reduced neutrophil infiltration and macrophage accumulation, enhanced angiogenesis,\nand increased collagen deposition. This study shows that TLXDS improves diabetes-impaired wound healing.
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