Background: Duodenal fibrolipoma and duodenum-jejunum intussusception are both rare occasions in clinical\npractice. The diagnosis of duodenal fibrolipoma mainly depends on endoscopy examination, supplemented by CT\nand MRI. As the tumor grows, some severe symptoms need surgical intervention. As the development of endoscopic\ntechniques, the operation plan should be made individually.\nCase presentation: A 47-year-old female with the complaint of upper abdominal pain and melena was reported.\nAbdominal examination revealed upper abdomen lightly tender and blood test showed severe anemia. Image and\nendoscopy examination exhibited â??a giantmassâ? in the descending (D2) part of duodenum, dragged by the tumor\ninto the distal intestinal canal and causing intussusception. Intermittent blood transfusion treatment, enteral and\nparenteral nutrition were adopted to adjust her general state. Two weeks later, the mass was resected together with\nthe basement intestinal wall via the jejunum incision and then the intussuscepted D2 part was restored. The paraffin\npathological diagnosis correlated with the preoperative judgment of fibrolipoma and the patient was discharged\nhealthy on POD 14.\nConclusions: Duodenal fibrolipoma is a rare disease, infrequently causing intussusception and severe upper GIB.\nDuodenoscopy and endoscopic ultrasound contribute to making an appropriate diagnosis, and for patients with\nsevere symptoms needed surgical intervention, operation plan should be individualized depending on the size and\nlocation of the lesion.
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