Diverse and significant benefits against cold/flu symptoms and seasonal allergies have been observed with a dried fermentate\n(DF) derived from Saccharomyces cerevisiae (EpiCor) in multiple published randomized trials. To determine if DF may influence\nother immune conditions, two separate animal studies were conducted. Study 1 examined the ability of DF to prevent or reduce\ninflammation when given orally for 14 days to rats prior to receiving 1% carrageenan (localized inflammation model). DF\nsignificantly (P < 0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control. Edema severity and PGE2\nlevels were reduced by approximately 50% and 25% (P < 0.05), respectively. Study 2 examined the ability of DF to treat established\ninflammation induced by type-2 collagen in mice over 4 weeks (autoimmune arthritis model). Significantly reduced arthritis\nscores, antibody response to type-2 collagen, and interferon-gamma levels were observed compared to controls (all parameters\nP < 0.05). DF favorably impacts multiple acute and potentially chronic immunologic inflammatory control mechanisms and\nshould be further tested in clinical trials.
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