Objective. To assess the effect of sulfotanshinone sodium injection for unstable angina. Methods. We searched for published\r\nand unpublished studies up to June 2011. We included randomized controlled trials that confoundedly addressed the effect of\r\nsulfotanshinone sodium injection in the treatment of unstable angina. Results. Twenty-five studies involving 2,377 people were\r\nincluded. There was no evidence that sulfotanshinone sodium alone had better or worse effects to routine western medicine\r\ntreatments in improving clinical symptoms (RR 1.00, 95% CI 0.90 to 1.11) and ECG (RR 0.97, 95% CI 0.87 to 1.09). However,\r\nthere was evidence that sulfotanshinone sodium combined with western medications was a better treatment option than western\r\nmedications alone in improving clinical symptoms (RR 1.28, 95% CI 1.23 to 1.3), ECG (RR 1.26, 95% CI 1.18 to 1.35), C-reaction\r\nprotein (mean difference 2.10, 95% CI 1.63 to 2.58), and IL-6 (mean difference -3.85, 95% CI -4.10 to -3.60). There was no\r\ndifference between sulfotanshinone sodium plus western medications and western medications alone affecting mortality (RR\r\n0.50, 95% CI 0.02 to 12.13). Conclusion. Compared with western medications alone, sulfotanshinone sodium combined with\r\nwestern medications may provide more benefits for patients with unstable angina. Further large-scale high-quality trials are\r\nwarranted.
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