Fetal/neonatal allo-immune thrombocytopenia (FNAIT) results from maternal\nimmunization against fetal platelet-specific antigens (HPA) inherited from the father. Most cases\ninvolve HPA located on glycoproteins (GP) IbIX, IaIIa and IIbIIIa. Iso-immunizations can also occur\nin the absence of expression of membrane proteins, such as GPIIb or GPIIIa in Glanzmann patients.\nCD36 (also called glycoprotein GPIV) deficiency is observed in 3 to 5% of Asian and African\npopulations. We report here the case of a 41-year-old Canadian woman originated from Africa, who\ndelivered a male dead new-born at 39 weeks of gestation. A massive intracranial haemorrhage was\nidentified as being the obvious cause of death. No platelet antibody against GPIbIX, IaIIa, and IIbIIIa\nwas identified by the gold-standard Monoclonal Antibody-specific Immobilization of Platelet\nAntigens (MAIPA) assay. Surprisingly, anti CD36 iso-antibodies were identified in the maternal\nserum with a new bead-based multiplex assay. The CD36 gene was sequenced for both parents, and\na mutation was identified on Exon 10 of the motherâ??s CD36 gene, which was absent for the father:\nNM_000072.3:c.975T>G inducing a STOP codon at position 325 of the mature protein. The absence\nof CD36 expression on the motherâ??s platelets was confirmed by flow cytometry.
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