Background. Erythrocyte sedimentation rate (ESR) is a valuable laboratory tool in evaluation of infectious, inflammatory, and\r\nmalignant diseases. Red blood cells in outside from the body precipitate due to their higher density than the plasma. In this study\r\nwe discuss the IVIG effect on ESR in different diseases and different ages. Methods and Materials. Fifty patients under 12 years old\r\nwho had indication to receive IVIG enrolled in this study. Total dose of IVIG was 2 gr/kg (400mg/kg in five days or 2 gr/kg in single\r\ndose). ESR before infusion of IVIG and within 24 hours after administration of the last dose of IVIG was checked. Results. 23 (46%)\r\npatients weremales and 27 (54%) were females. The mean of ESR before IVIG was 31.8�±29.04 and after IVIG it was 47.2�±36.9; this\r\ndifference was meaningful (?? = 0.05). Results of ESR changes in different age groups, 6 patients less than 28 days, 13 patients from\r\n1 month to 1 year, 20 patients from 1 to 6 years old, and 11 patients from 6 to 12 years have beenmeaningful (?? = 0.001, ?? = 0.025,\r\nand ?? = 0.006, resp.). Conclusion. In patients who are receiving IVIG as a therapy, ESR increased falsely (noninflammatory rising);\r\ntherefore use of ESR for monitoring of response to treatment may be unreliable. Although these results do not apply to neonatal\r\ngroup, we suggest that, in patients who received IVIG, interpretation of ESR should be used cautiously on followup.
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