This present paper presents an analytical description and numerical simulations of the influence of macroscopic intercell dose\nvariations and intercell sensitivity variations on the probability of controlling the tumour. Computer simulations of tumour control\nprobability accounting for heterogeneity in dose and radiation sensitivity were performed. An analytical expression for tumor\ncontrol probability accounting for heterogeneity in sensitivity was also proposed and validated against simulations. The results\nshow good agreement between numerical simulations and the calculated TCP using the proposed analytical expression for the\ncase of a heterogeneous dose and sensitivity distributions.When the intratumour variations of dose and sensitivity are taken into\naccount, the total dose required for achieving the same level of control as for the case of homogeneous distribution is only slightly\nhigher, the influence of the variations in the two factors taken into account being additive.The results of this study show that the\ninterplay between cell or tumour variation in the sensitivity to radiation and the inherent heterogeneity in dose distribution is\nhighly complex and therefore should be taken into account when predicting the outcome of a given treatment in terms of tumor\ncontrol probability.
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