The aim of this study was to explore effects on anxiety-like behavior of D1 dopamine receptor agonist, SKF-38393, and of\nD1 dopamine receptor antagonist, SCH-23390, given alone or in combination with a low dose of 17????-estradiol (17????-E2) to\novariectomized (OVX) rats. Two weeks after surgery, OVX rats began 14 days of treatment with the vehicle, a low dose of 17????-\nE2 (5.0 ????g/rat, s.c.), SKF-38393 (0.1mg/kg, i.p.), SCH-23390 (0.1mg/kg, i.p.), SKF-38393 plus 17????-E2, or SCH-23390 plus 17????-\nE2. The animals were tested in the black and white model (BWM) and the open field test (OFT). SCH-23390 (0.1mg/kg, i.p.)\nalone or in a combination with a low dose of 17????-E2 (5.0 ????g/rat, s.c.) resulted in anxiolytic-like effect in OVX rats in the BWM.\nRepeated treatment with SCH-23390 and 17????-E2 profoundly increased anxiolytic-like effect of single substances exerted per se.\nCoadministration of SCH-23390 with 17????-E2 increased frequency of rearing and grooming in OVX rats in OFT. SKF-38393\n(0.1mg/kg, i.p.) treatment failed to alter anxiety-like behavior in OVX rats in the BWM. The results of the present study suggest\nthat 17????-E2 and SCH-23390 interact to exert anxiolytic-like action and that each of these drugs can potentiate effects of each other.
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