The primary focus of this study was to highlight the impact of magnetite particles on systemic circulation. Magnetite which is a magnetic component used in magnetic targeted system composition, revealed absorption and its appearance in systemic circulation showcased through changes in the heamogram. Tablet dosage form based on the magnetic drug delivery concepts was developed successfully using model drug candidate imatinibmesylate, which is an anticancer drug. Certain magnetic system suitability parameters were focused and evaluated in the present research work to validate the magnetic system comprising oral tablets. Drug release patterns were also found to have impact of polymers and magnet which are in-vitro component used in the system. The cancer therapy is prolonged therapy, one time dosage of magnetite may show recovery from changed heamogram and heamolysis data but continued absorption of magnetite even though coated with suitable polymer after long term use may create dysfunctioning of normal body mechanisms either after release of coat or even if coat remains for years long, accumulation of magnetite in body system may be harmful. So ultimately the present study indicates that long term safety of magnetic drug delivery system cannot be predicted even though magnetic drug delivery tablet system for oral use was successfully validated and developed.
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