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Inventi Impact: Advanced Dosaging

Articles

  • Inventi:pad/66/12
    EFFICACY OF SINGLE-DOSE AND TRIPLE-DOSE ALBENDAZOLE AND MEBENDAZOLE AGAINST SOIL-TRANSMITTED HELMINTHS AND TAENIA SPP.: A RANDOMIZED CONTROLLED TRIAL
    31-Mar-2012 Research 2012 : April - June
    Peter Steinmann, Jurg Utzinger, Zun-Wei Du, Jin-Yong Jiang, Jia-Xu Chen, Jan Hattendorf, Hui Zhou, Xiao-Nong Zhou

    Background: The control of soil-transmitted helminth (STH) infections currently relies on the large-scale administration of\nsingle-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm\nand Trichuris trichiura in terms of cure rates (CR), whereas fecal egg reduction rates (ERR) are generally high for all common\nSTH species. We compared the efficacy of single-dose versus triple-dose treatment against hookworm and other STHs in a\ncommunity-based randomized controlled trial in the Peopleââ?¬â?¢s Republic of China.\nMethodology/Principal findings: The hookworm CR and fecal ERR were assessed in 314 individuals aged $5 years who\nsubmitted two stool samples before and 3ââ?¬â??4 weeks after administration of single-dose oral albendazole (400 mg) or\nmebendazole (500 mg) or triple-dose albendazole (36400 mg over 3 consecutive days) or mebendazole (36500 mg over 3\nconsecutive days). Efficacy against T. trichiura, Ascaris lumbricoides, and Taenia spp. was also assessed. Albendazole cured\nsignificantly more hookworm infections than mebendazole in both treatment regimens (single dose: respective CRs 69%\n(95% confidence interval [CI]: 55ââ?¬â??81%) and 29% (95% CI: 20ââ?¬â??45%); triple dose: respective CRs 92% (95% CI: 81ââ?¬â??98%) and\n54% (95% CI: 46ââ?¬â??71%)). ERRs followed the same pattern (single dose: 97% versus 84%; triple dose: 99.7% versus 96%). Tripledose\nregimens outperformed single doses against T. trichiura; three doses of mebendazole ââ?¬â?? the most efficacious treatment\ntested ââ?¬â?? cured 71% (95% CI: 57ââ?¬â??82%). Both single and triple doses of either drug were highly efficacious against A.\nlumbricoides (CR: 93ââ?¬â??97%; ERR: all .99.9%). Triple dose regimens cured all Taenia spp. infections, whereas single dose\napplications cured only half of them.\nConclusions/Significance: Single-dose oral albendazole is more efficacious against hookworm than mebendazole. To\nachieve high CRs against both hookworm and T. trichiura, triple-dose regimens are warranted.

    How to Cite this Article
    CC Compliant Citation: Steinmann P, Utzinger J, Du Z-W, Jiang J-Y, Chen J-X, et al. (2011) Efficacy of Single-Dose and Triple-Dose\nAlbendazole and Mebendazole against Soil- Transmitted Helminths and Taenia spp.: A Randomized Controlled Trial. PLoS ONE 6(9):\ne25003. doi:10.1371/journal.pone.0025003.
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