The current focus in development of cancer therapies is on targeted drug delivery to provide therapeutic concentrations of anticancer agents at the site of action and spare the normal tissues. There are a variety of different delivery strategies that are either currently being used or are in the testing stage to treat human cancers which are discussed in this review. In that first of Nano particles can be used in targeted drug delivery at the site of disease to improve the uptake of poorly soluble drugs, the targeting of drugs to a specific site, and drug bioavailability. In that second drug delivery to brain tumors, since the brain is the most sensitive and complex organ in the human body and it would not make sense for it to become the battleground of infection and immune response. The usual noninvasive approach to solving the brain drug delivery problem is to lipidize the drug, The water -soluble parts of the drugs restricts blood brain barrier transport conversion of water-soluble drug into lipid-soluble pro drug is the traditional chemistry driven solution to the blood brain barrier problem.
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