Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD\n(pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our\n600-bed university-affiliated teaching hospital, we conducted a tigecycline efficacy review over\na three-month period in 34 evaluable patients. Parameters assessed included clinical response, cure or\ntreatment failure, once daily as q12h dosing, maintenance dosing, high dose vs. standard loading\nregimens, adverse effects, and the effect of infectious disease consultation on outcomes. Results:We found\nonce daily high dose tigecycline (HDT) was highly effective in treating serious systemic infections due to\nMDR Gram-positive/negative pathogens as well as C. difficile colitis. Adverse effects were infrequent and\nlimited to mild nausea/vomiting. Once daily HDT was highly effective, and the few treatment failures\nwere related to suboptimal/split dosing regimens. Conclusion: Once daily HDT was highly effective\nwhen used to treat susceptible pathogens and when optimally dosed, i.e., 200ââ?¬â??400 mg (IV) loading dose\nÃ?â??1, followed by a once daily maintenance dose of 100ââ?¬â??200 mg (IV) q24h.
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