Combination of chemotherapy and immunotherapy has been a promising strategy in cancer\ntreatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine,\nhave been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive\ntumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide)\nwas constructed. In this system, Angelica polysaccharides act as not only carriers to targeted\ndelivery of drugs to tumor tissue but also eectors to improve tumor microenvironment and enhance\nimmune function, resulting in synergistic antitumor eect with chemotherapy drugs. The structure\nof this conjugate was confirmed by FI-IR and 1H-NMR. The particle size and zeta potential of\nthe nanoparticles were................................................................................................
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