Backgrounds: Magnesium has been known for its antioxidative and antiinflammatory properties in many studies.\r\nIn this study two dosing regimens of magnesium were compared with a placebo control group in order to\r\ninvestigate safety and efficacy of high doses of intravenous magnesium sulfate infusion on critically ill trauma\r\npatients. Inflammatory and oxidative factors were measured in this trial.\r\nMethods: 45 trauma patients with systemic inflammatory response syndromes (SIRS) were randomly assigned into\r\n2 treatment and one placebo groups. The high dose group received 15 g MgSO4, low dose group received 7.5 g\r\nof MgSO4 over 4 hour infusion, and placebo group received saline alone. The initial and post magnesium sulfate\r\ninjections levels of tumor necrosis factor alpha (TNF-a), total antioxidant power and lipid peroxidation were\r\nmeasured after 6, 18 and 36 hours. The pre-infusion along with 6 and 36 hour level of microalbuminuria were\r\nalso determined.\r\nResults: Repeated measurements illustrated that there was no significant difference in TNF-a, total antioxidant\r\npower and lipid peroxidation levels among groups during the period of analysis. The microalbuminuria at 36 hour\r\npost infusion of high dose group was lower than that of control group (p = 0.024). Patient�s mortality (28 day) was\r\nsimilar among all treatment groups. Both magnesium infusion groups tolerated the drug without experiencing\r\nany complications.\r\nConclusion: No evidence for antioxidative and antiinflammatory effects of magnesium in traumatic SIRS positive\r\npatients was found. Magnesium in high doses may be recommended for traumatic patients with SIRS status to\r\nprevent microalbuminuria.
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