The effectiveness of Okra gum in sustaining the release of propranolol hydrochloride in a tablet was studied. Okra gum was\r\nextracted from the pods of Hibiscus esculentus using acetone as a drying agent. Dried Okra gum was made into powder form and\r\nits physical and chemical characteristics such as solubility, pH, moisture content, viscosity, morphology study using SEM, infrared\r\nstudy using FTIR, crystallinity study using XRD, and thermal study using DSC and TGA were carried out. The powder was used\r\nin the preparation of tablet using granulation and compression methods. Propranolol hydrochloride was used as a model drug and\r\nthe activity of Okra gum as a binder was compared by preparing tablets using a synthetic and a semisynthetic binder which are\r\nhydroxylmethylpropyl cellulose (HPMC) and sodium alginate, respectively. Evaluation of drug release kinetics that was attained\r\nfromdissolution studies showed that Okra gum retarded the release up to 24 hours and exhibited the longest release as compared to\r\nHPMC and sodium alginate. The tensile and crushing strength of tablets was also evaluated by conducting hardness and friability\r\ntests. Okra gum was observed to produce tablets with the highest hardness value and lowest friability.Hence,Okra gum was testified\r\nas an effective adjuvant to produce favourable sustained release tablets with strong tensile and crushing strength.
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