Objective. This study uses the acute otitis media clinical practice guideline proposed in 2004 as a reference to evaluate whether\r\nantibiotics doses that are in line with the recommendations lead to better prognosis. The study also attempts to clarify possible\r\nfactors that influence the outcome. Study Design. Retrospective cohort study. Subjects and Methods. A total of 400 children with\r\nacute otitis media were enrolled.The dosage of amoxicillin was considered to be appropriate when in accord with clinical practice\r\nguidelines, that is, 80ââ?¬â??90mg/kg/day. The outcome was defined according to the description of tympanic membrane on medical\r\nrecords.Multivariate logistic regressionwas used to analyze the relationship between antibiotic dosage and prognosis after adjusting\r\nfor baseline factors. Results. The majority of prescriptions were under dosage (89.1%) but it was not noticeably associated with\r\noutcome (P= 0.41).Thecorrelation between under dosage and poor prognosis was significant in children below20 kgwith bilateral\r\nacute otitis media (odds ratio 1.63; 95% CI 1.02ââ?¬â??2.59,P = 0.04). Conclusion. Treating acute otitis media in children, high-dose\r\namoxicillin with clavulanate as recommended in the clinical practice guideline was superior to conventional doses only in children\r\nunder 20 kg with bilateral diseases.
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