To study brain type natriuretic peptide (BNP) and aldosterone (AL) levels in patients with postinfarction cardiosclerosis (PICS) complicated by chronic heart failure (CHF) functional classes (FC) II and III and identify relationship between the changes in the levels of these neurohormones and severity of CHF and localization of myocardial infarction. Examined 92 patients with PICS complicated by CHF. Patients having myocardial infarction within 6 months – 3 years were randomly selected. NYHA classes were determined analyzing six-minute walk test (6′WT). Patients with FC II CHF were 48, and FC III - 44 patients. In patients with CHF, activation of the neurohumoral factors were marked which characterized by increasing concentrations of BNP and aldosterone in all examined patients. Mid-high increase in BNP was noted in 54.3% of examined patients, aldosterone in 62.8% of patients. High level of BNP, i.e. values above the median, was observed in 45.7% and aldosterone - in 37,2% of patients with FC II CHF. Patients with FC II had more mid-high levels of neurohumoral factors, whereas in patients with FC III noted the predominance of high levels of BNP and aldosterone. According to ECG and past history, 19 patients (54.3%) had anterior MI, while 16 patients (45,7%) had posterior MI. 68.4% patients with FC II experiencing anterior MI had high BNP level, whereas 81.2% patients had mid-high level of this hormone in the posterior localization. Similar changes were observed in patients with FC III. Patients with PICS complicated by CHF had elevated levels of BNP and Al in blood and levels of these neurohumoral markers correlate with the severity of CHF. High level of BNP and AL, regardless of severity of CHF was observed mainly in anterior M.
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