Quetiapine belongs to novel antipsychotic and can used as a first line antipsychotic in the treatment of psychosis. It improves cognitive function and overall global functioning by improving psychopathologies. The aim was to find out the effect of quetiapine as a cognitive restorer in acute schizophrenia. 46 patients of acute schizophrenia attended to OPD at Patna Medical College, Patna were treated with optimal dose of quetiapine 300 mg/day. The initial cognitive function scored on MMSE and VIQ on WAISR (Indian adaptation) was recorded and repeated at two occasions at an interval of 4 weeks. The analysis of obtained data showed improvement from baseline at the end of fourth week but during 4th to 8th week interval was not significant. The overall improvement in cognition was noted at end of 8th week. VIQ showed significant improvement throughout the study at every time of measurement except a digit span which showed significant improvement only at the end of 8th week. The quetiapine has the ability to improve cognitive function. The major changes noted in global functioning during initial 4 weeks of treatment. So that quetiapine act as a cognitive restorer.
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