Objective: To observe the effect of liquefying the necrotic tendons of diabetic foot and promotion\nof wound healing using the treatment of Huafu Zaisheng. Methods: 98 patients suffering from diabetic\nfoot were randomly divided into Huafu Zaisheng group (35 cases), Huafu group (32 cases),\nZaisheng group (31 cases), and then had eroded debridement timely for its wounds. Since then,\ndifferent methods and drugs applied to deal with the wound, observe the liquefaction time and\ndetachment time of the degeneration and necrosis tendon, and observe the wound healing. Collection\nand preservation of wound secretion, determine the pH value of wound secretion, determination\ncontent of the NO and TGF-1 in wound secretion. Wound tissue containing fascia and tendons\nwas extracted by surgical methods, before treatment and 6, 12 weeks after treatment. All tissue\nsamples were prepared according to Hematoxylin-eosin staining techniques, after which their\nappearance was evaluated for pathological changes using an optical microscope. Immunohistochemistry\nstaining was used to detect the expressions of CD34 and CK19. Results: By comparison\nof the efficacy of the three groups, the curative effect of the HFZS group is superior to HF and ZS\ngroup. The necrotic tendons of Huafu Zaisheng group were liquefied clearer than the other two\ngroups. Three groups of secretions pH value were the trend of first decreased, then increased,\nweakly basic first, and then weak acid, and then close to neutral. Compared to ZS group and HF\ngroup, the difference was statistically significant (P < 0.01). After 4.6 weeks� treatment, compared\nto ZS group and HF group, the NO, TGF-1 content of HFZS group increased significantly, and the\ndifference was statistically significant (P < 0.01). Conclusion: Using the method of Huafu Zaisheng,\nthe necrotic tendons and tissues could be liquefied as early as possible, and then promote the\nwound healing. Application of Huafuzaisheng method to deal with wounds, can remove necrotic\ntendons and fascia tissue as early as possible, can change the wound pH value and provide a variety\nof active factors (NO, TGF-1) and micro-environment for wound healing.
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