Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia\nonset to treatment, the affected brain region, and its size. The main targets of ischemic stroke therapy aim to restore tissue\nperfusion in the ischemic penumbra in order to decrease the total infarct area by maintaining blood flow. Advances in research\nof pathological process and pathways during acute ischemia have resulted in improvement of new treatment strategies apart from\nrestoring perfusion. Additionally, limiting the injury severity by manipulating the molecular mechanisms during ischemia has\nbecome a promising approach, especially in animal research.The purpose of this article is to review completed and ongoing phases\nI and II trials for the treatment of acute ischemic stroke, reviewing studies on antithrombotic, thrombolytic, neuroprotective, and\nantineuroinflammatory drugs that may translate into more effective treatments.
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