Background: Use of a reliable contraception method has become an inclusion criterion in prevention trials to\nminimize time off product. We report on hormonal contraceptive prevalence, uptake, sustained use and correlates\nof use in the Microbicides Development Programme (MDP 301) trial at the Masaka Centre in Uganda.\nMethods: HIV negative women in sero-discordant relationships were enrolled and followed-up for 52 to 104 weeks\nfrom 2005 to 2009. Contraceptive use data was collected through self-report at baseline and dispensing records\nduring follow-up. Hormonal contraceptives were promoted and provided to women that were not using a reliable\nmethod at enrolment. Baseline contraceptive prevalence, uptake and sustained use were calculated. Uptake was\ndefined as a participant who reported not using a reliable method at enrolment and started using a hormonal\nmethod at any time after. Logistic regression models were fitted to investigate predictors of hormonal\ncontraceptive uptake.\nResults: A total of 840 women were enrolled of whom 21 aged ââ?°Â¥50 years and 12 without follow-up data were\nexcluded; leaving 807 (median age 31 IQR 26ââ?¬â??38) in this analysis. At baseline, 228 (28%) reported using a reliable\ncontraceptive; 197 hormonal, 28 female-sterilisation, two IUCD and one hysterectomy. As such 579 were not using\na reliable contraceptive at enrolment, of whom 296 (51%) subsequently started using a hormonal contraceptive\nmethod; 253 DMPA, four oral pills, and two norplant. Overall 193 (98%) existing users and 262 (88%) new users\nsustained use throughout follow-up. Independent correlates of hormonal contraceptive uptake were: younger\nwomen ââ?°Â¤30 years, aOR = 2.5, 95% CI: 1.7ââ?¬â??3.6 and reporting not using contraceptives at baseline due to lack of\naccess or money, breastfeeding or other reasons, in comparison to women who reported using unreliable method.\nConclusion: Promotion and provision of hormonal contraception doubled the proportion of women using a\nreliable method of contraception. Uptake was pronounced among younger women and those not previously using\na reliable method because of lack of access or money, and breastfeeding. Promotion and provision of hormonal\ncontraceptives in trials that require the interruption or discontinuation of investigational products during pregnancy\nis important to reduce the time off product.
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