Background: The clinical effect of bisphosphonate treatment has not been clearly evaluated by kidney function in\nJapanese Chronic Kidney Disease (CKD) patients with osteoporosis. This study analyzed the data from three risedronate\nJapanese phase III trials. The clinical effect of risedronate therapy was evaluated in CKD patients with osteoporosis.\nMethods: The Japanese clinical trials involved 852 subjects who received risedronate (2.5 mg once daily or 17.5 mg\nonce weekly) and whose estimated glomerular filtration rate (eGFR) were calculable and at � 30 mL/min. The subjects\nwere divided into subgroups according to the eGFR level: � 90 mL/min/1.73 m2, � 60 to < 90 mL/min/1.73 m2, � 30\nto < 60 mL/min/1.73 m2. Lumbar spine bone mineral density (BMD), bone turnover markers (BTMs) and adverse events\nwere evaluated at 48 weeks.\nResults: Adverse event incidence was similar among three subgroups. There was also no exacerbation of impaired\nkidney function associated with risedronate administration in the subjects with eGFR above 30 mL/min/1.73 m2.\nRisedronate administration induced a significant increase in lumbar spine BMD and significant inhibition of BTMs in\nthree subgroups.\nConclusions: The risedronate therapy showed similar clinical effects in CKD patients with osteoporosis compared to\nthose without CKD.
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