Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on\nphysiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and\nsaliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers\nwere recruited to receive 125 mL of red wine naturally lacking of MLT (placebo, PLC), or the same\nwine enriched with MLT (MLT+). A physiological steady decline of serum MLT was observed from\nbaseline up to 90 min, for both wines. After PLC intake, the decrease was significantly faster than the\none occurring after MLT+ wine, which thus delayed the drop down of serum MLT with a plateau at\n30â??60 min. Salivary MLT levels slightly peaked at 45 min after MLT+ wine intake, without statistical\nsignificance. Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of\nthe indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the\nhormone into the bloodstream.
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