One of the most common post-operative complications of tooth extraction is pain.\nOral analgesics, namely loxoprofen sodium and diclofenac potassium, are often prescribed; however,\nthe efficacy of these drugs irrespective of gender and type of extraction has not been tested. Therefore,\nthis study aimed to compare the efficacy of these two drugs in post-dental extraction pain relief among\nmale and female patients in cases of simple and surgical tooth extraction. A single-center, triple-blind,\nrandomized clinical trial was conducted among 100 male and female patients who underwent\ntooth extraction at Taibah University Dental College and Hospital in Al-Madinah, Saudi Arabia.\nThe patients reported their pain post-operatively after 6 hours and every 12 h for 3 days using the\nVerbal Descriptor Scale (e.g., â??no painâ?, â??mild painâ?). Descriptive statistics and chi-square tests were\nrun to analyze the data. An equal number of patients received either the drug loxoprofen sodium\nor diclofenac potassium and completed the study follow-up. Patients allocated to the diclofenac\npotassium drug group after 36 h were statistically significantly in their reporting of â??no painâ? and\nâ??mild painâ? compared to patients allocated to the loxoprofen sodium group (86% vs. 66%, respectively;\np = 0.019), irrespective of gender or type of tooth extraction. However, both groups demonstrated\ncomparable (p > 0.05) post-operative pain relief over the other aforementioned allocated time intervals.\nIn conclusion, the diclofenac potassium group had slightly better control over post-operative pain\nthan the group receiving loxoprofen sodium.
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