Background: Iron deficiency without anemia is related to adverse symptoms that can be relieved by\r\nsupplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact\r\nof iron treatment after a blood donation.\r\nMethods: One week after donation, we randomly assigned 154 female donors with iron deficiency without\r\nanemia, aged below 50 years, to a four-week oral treatment of ferrous sulfate versus a placebo. The main outcome\r\nwas the change in the level of fatigue before and after the intervention. Aerobic capacity, mood disorder, quality\r\nof life, compliance and adverse events were also evaluated. Hemoglobin and ferritin were used as biological\r\nmarkers.\r\nResults: The effect of the treatment from baseline to four weeks of iron treatment was an increase in hemoglobin\r\nand ferritin levels to 5.2 g/L (P < 0.01) and 14.8 ng/mL (P < 0.01), respectively. No significant clinical effect was\r\nobserved for fatigue (-0.15 points, 95% confidence interval -0.9 points to 0.6 points, P = 0.697) or for other\r\noutcomes. Compliance and interruption for side effects was similar in both groups. Additionally, blood donation\r\ndid not induce overt symptoms of fatigue in spite of the significant biological changes it produces.\r\nConclusions: These data are valuable as they enable us to conclude that donors with iron deficiency without\r\nanemia after a blood donation would not clinically benefit from iron supplementation.
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