In present study, clinical adverse events of lamivudine was analysed in hepatitis b patients. Clinical data were collected from hepatitis b patients that presented with serious adverse reactions to lamivudine. We examined 100 patients of hepatitis b who were treated with lamivudine in i.k.d.r.c, civil hospital, Ahmedabad from January 2009 to February 2011. The main adverse reaction were headache, joint pain, back pain, cough, lymphadenopathy, acidity, fatigue. The hepatitis b was seen more in the 20 to 30 year of age and 40 to 50 year of age. The male was more prone to hepatitis b than the female. The adverse reactions were related to lamivudine, but the biological mechanism of the reaction is not clear. Combination therapy with interferon or other nucleoside analogues may increase the risk of adverse reaction.
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