The improper use of drugs can leads to patient morbidity and even mortality. In general, problems related to the use\r\nof approved drugs can be summarized with the term drug therapy problems. This study was aimed to evaluate the drug therapy\r\nproblems in a south Indian tertiary care teaching hospital. Prospective observational study conducted in the Department of\r\nGeneral Medicine, Rajiv Gandhi Institute of Medical Sciences, Kadapa for the period of six months. Patients are randomly\r\nenrolled in the study based on inclusion and exclusion criteria. This study was approved by institutional ethical committee,\r\nRIMS, Kadapa. Adverse drug reactions were identified according to the manifestations on the patients and were notified and\r\nreported to the physician and were documented in ADR form, these ADR were classified according to Naranjo�s scale. Other drug\r\nrelated problems like untreated indication, improper drug selection, sub therapeutic dose, drug use without indication, over\r\ndosage and failure to receive drugs were analyzed from the prescription and referred from standard literature. Major\r\npredisposing risk factors were polypharmacy, age, gender and immune suppression were identified. Clinical pharmacists are the\r\nupcoming breed of pharmacists in our country.
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