Nifedipine-solid-lipid nanoparticles lyophilized with trehalose (NI-SLN-Tre) were prepared by the\nhigh pressure homogenization of a roll mixture consisting of NI and hydrogenated soybean phosphatidylcholine\nand dipalmitoylphosphatidylglycerol, and in vivo pharmacokinetic properties and\ntheir hemocompatibility were determined and compared with those of a NI-SLN suspension. The\nresulting pharmacokinetic data demonstrated that although no significant differences were observed\nbetween the time of peak concentration (Tmax), peak plasma concentration (Cmax), and the\narea under the curve (AUC o??) values of both administrated samples, NI tended to be absorbed to\na much greater extent from the lyophilized NI-SLN-Tre suspensions because of the enhanced solvation\nof NI-SLN in gastrointestinal fluid, derived from formation of hydrogen bonds between the\npolar head groups of the lipids and the O-H groups of trehalose. Furthermore, the results of a hemolysis\nassay revealed that the NI-SLN and NI-SLN-Tre suspensions showed good hemocompatibility\nproperties with hemolysis values of less than 5%. Taken together, the results of this study\ndemonstrate that NI-SLN-Tre exhibits suitable pharmacokinetic properties and good biocompatibility.
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