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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/19298/16
    Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different\nRoutes to Llamas (Lama glama)
    01-Jan-1970 Research 2016 : April - June
    Veronica Kreil, Luis Ambros, Ana Paula Prados, Lisa Tarragona, Agustina Monfrinotti, Guillermo Bramuglia, Marcela Rebuelto

    We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV),\nintramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some\nEscherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage\nrecommendations for this species could be made. Six llamas received immediate (10mg/kg, IV, IM, and SC) and sustained (8mg/kg\nIM, SC) release cephalexin. Pharmacokinetic parameters were calculated by noncompartmental approach. Immediate release SC\nadministration produced a significantly longer elimination half-life as compared with the IV and IM administration (1.3 Ã?± 0.2\nversus 0.6 Ã?± 0.1 and 0.6 Ã?± 0.1 h, resp.) and higher mean absorption time as compared with the IM administration (1.7 Ã?± 0.5 versus\n0.6 Ã?± 0.4 h). Absolute bioavailability was in the range of 72ââ?¬â??89% for both formulations and routes of administration. Cephalexin\nMIC90 values against staphylococci and E. coli were 1.0 and 8.0

    How to Cite this Article
    CC Compliant Citation: Veronica Kreil, Luis Ambros, Ana Paula\nPrados, et al., â??Pharmacokinetics of Immediate and Sustained\nRelease Cephalexin Administered by Different Routes to Llamas\n(Lama glama),â? Advances in Pharmacological Sciences, vol. 2016,\nArticle ID 4621039, 6 pages, 2016. doi:10.1155/2016/4621039,\nhttp://creativecommons.org/licenses/by/4.0/.
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