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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/21704/17
    Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
    01-Jan-1970 Research 2017 : January - March
    Patcharanee Tawasri, Chadarat Ampasavate, Somsak Tharatha, Natthakarn Chiranthanut, Supanimit Teekachunhatean

    Theobjective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on\npharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following\noral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive\neither one of the two regimens: (1) a single dose of 3,000mg of the Ling Zhi preparation or (2) a single dose of 3,000mg of the Ling\nZhi preparation in combination with 2,500mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched\nto receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points\nfor 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry\n(LC-MS).The pharmacokinetic parameters analyzed were maximal plasma concentration (

    How to Cite this Article
    CC Compliant Citation: Patcharanee Tawasri, Chadarat\nAmpasavate, Somsak Tharatha, Natthakarn Chiranthanut, and\nSupanimit Teekachunhatean, â??Effect of Oral Coadministration of\nAscorbic Acid with Ling Zhi Preparation on Pharmacokinetics of\nGanoderic Acid A in Healthy Male Subjects: A Randomized\nCrossover Study,â? BioMed Research International, vol. 2016,\nArticle ID 2819862, 7 pages, 2016. doi:10.1155/2016/2819862,\nhttp://creativecommons.org/licenses/by/4.0/.
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