The objective of proposed work was to develop, formulate and evaluate bi-layer tablet containing Metoprolol succinate as extended release form and Ramipril as immediate release form. Acting by different mechanisms, metoprolol succinate and ramipril in combination would produce an additive antihypertensive effect. Although an enhanced antihypertensive effect can be obtained by using a larger dose of a single drug, this may increase the incidence of side effects. Using low doses of the two drugs in combination would achieve better reduction in BP without compromising tolerability. Both extended release and immediate release part were formulated by wet granulation method. The granules were evaluated and compressed by using Bilayer compression machine. The prepared bilayer tablets were evaluated and in vitro dissolution test was carried out separately for Ramipril and Metoprolol succinate. Different formulations were developed for Metoprolol succinate and Ramipril separately, based on trial and error basis and evaluated. The optimized formulation was found to be comparable in drug release profile as per USP 2007 in case of metoprolol succinate layer and as per IP 2007 in case of ramipril layer. A broad range of drug release pattern could be achieved by varying polymer ratio in extended release part; binder and disintegrant ratio in immediate release part. Utilizing the experimental design concept, an effective formulation has been developed with extended release Metoprolol succinate and immediate release Ramipril in the form of Bilayer tablet to optimize therapy of Hypertension and Myocardial Infarction.
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